- Sabra (Marvel)
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- Sasquatch (Marvel)
- Satana Hellstrom (Marvel)
- Secret (DC)
- Sersi (Marvel)
- Shadowcat (Marvel)
- Shaman (Marvel)
- Shamrock (Marvel)
- Shanna the She Devil (Marvel)
- Shatterstar (Marvel)
- She Hulk (Marvel)
- She Thing (Marvel)
- She Venom (Marvel)
- Shikari (DC)
- Shrinking Violet (DC)
- Silhouette (Marvel)
- Silk Spectre (DC)
- Silver Fox (Marvel)
- Silver Sable (Marvel)
- Silver Surfer (Marvel)
- Silverclaw (Marvel)
- Siryn (Marvel)
- Skids (Marvel)
- Slipstream (Marvel)
- Snowbird (Marvel)
- Solo (Marvel)
- Speedy II (DC)
- Spider Girl (DC)
- Spider Girl (Marvel)
- Spider Man (Marvel)
- Spider Woman (Marvel)
- Spitfire (Marvel)
- Spoiler (DC)
- Squirrel Girl (Marvel)
- Stacy X (Marvel)
- Star Spangled Kid (DC)
- Starfire (DC)
- Stargirl (DC)
- Static (DC)
- Stature (Marvel)
- Steel (DC)
- Stepford Cuckoos (Marvel)
- Storm (Marvel)
- Strong Guy (Marvel)
- Stunner (Marvel)
- Sun Boy (DC)
- Sun Girl (Marvel)
- Sunspot (Marvel)
- Superboy (DC)
- Supergirl (DC)
- Superman (DC)
- Superwoman (DC)
- Surge (Marvel)
- Swordsman (Marvel)